Influence of high-dose atorvastatin on inflammatory factors in patients with acute cerebral infarction

Objective To observe the influence of high-dose atorvastatin treatment on inflammatory factors in patients with acute cerebral infarction(ACI).Methods According to the results of carotid artery ultrasound,136 cases of patients with ACI were divided into carotid vulnerable plaque group and carotid stable plaque group in each of which had 68 cases.34 cases were both randomly selected in two groups and given a small dose(low-dose group) and high dose atorvastatin(high-dose group) treatment.Blood lipoprotein,high sensitivity C-reactive protein(hs-CRP),interleukin-17(IL-17) and marix metalloproteinase-9(MMP-9) were detected before treatment and after treatment for 2 weeks.Results After treatment,levels of LDL-C,TG,TC,hs-CRP,IL-17 and MMP-9 were significantly decreased in both groups(P0.01),which in high-dose group were lower than those in low-dose group(P0.05 or 0.01).Conclusion High-dose atorvastatin could rapidly reduce serum inflammatory factors in patients with ACI,thus might have the stronger anti-inflammation function and improve the stability of vulnerable plaque.