Effect of 40mg Short-term Atorvastatin on Inflammatory Factors in Patients with Acute Coronary Syndrome

【Objective】To observe the effect of short-term atorvastatin on the inflammatory factors such as high sensitivity C-reactive protein(hs-CRP) and interleukin-6(IL-6) in patients with acute coronary syndrome,and to demonstrate that atorvastatin could aggressively inhibit inflammation and stabilize the atherosclerosis plaque.【Methods】A randomized,double-blinded and parallel control design was made for this study.70 cases of selected acute coronary syndrome patients were randomly divided into conventional group(n=35) and atorvastatin group(n=35).Patients in the conventional group received conventional treatment without lipid-lowing drugs,whereas patients in atorvastatin group received atorvastatin 40 mg daily besides conventional treatment.Blood lipoprotein,hsCRP and IL-6 were measured in all patients before treatment,three days after drug therapy and 48 hours after PCI.【Results】Hs-CRP and IL-6 decreased significantly(P0.05) in atorvastatin group,while there was no significant change in the conventional group.hs-CRP and IL-6 significantly increased 48 hours after PCI in both group,however the elevated levels of hs-CRP and IL-6 were significantly lower in atrovastatin group than those in the conventional group. 【Conclusion】Atorvastatin could rapidly reduce serum inflammatory factors in patients with acute coronary syndrome,thus might inhibit inflammation and stabilize atherosclerosis plaque.