2004•Zhongguo xin yao zazhiRequires access

Synthesis of antihypertensive telmisartan

Guoqiang Su

Abstract

Objective:To synthesize telmisartan and optimize the process.Methods:Telmisartan was synthesized by steps of esterification,acylation,nitration,catalyze hydrogenation,cylization、hydrolysis,condensation,N-alkylation and hydrolysis.Results:Chemical structure of telmisartan was conformed by element analysis,UV,1HNMR and EI etc.Conclusion:This synthetic method was feasible.

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Available abstract

Key concepts: Telmisartan, Acylation, Chemistry, Hydrolysis, Alkylation, Organic chemistry, Condensation, Nitration