Yan Li-xue
Abstract
Objective:To synthesize telmisartan.Method:Telmisartan was prepared form 2-n-propyl-4-methyl-6-(methoxycarbonyl) benzimidazole by a 3-step process of cyclization,condensation,and hydrolysis.Results:The total yield of telmisartan was 45.6%.Conclusion:The method increases telmisartan yield,simplifies its process and decreases the cost.
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Objective:To synthesize telmisartan.Method:Telmisartan was prepared form 2-n-propyl-4-methyl-6-(methoxycarbonyl) benzimidazole by a 3-step process of cyclization,condensation,and hydrolysis.Results:The total yield of telmisartan was 45.6%.Conclusion:The method increases telmisartan yield,simplifies its process and decreases the cost.
Key concepts: Telmisartan, Yield (engineering), Chemistry, Hydrolysis, Condensation, Benzimidazole, Combinatorial chemistry, Pharmacology