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New and Improved Synthesis of Telmisartan: An Antihypertensive Drug

Ankesh Kumar, Samir Ghosh, G. N. Mehta, R. Soundararajan, P.S. Sarma, Kale Bhima

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Abstract

An improved, cost-effective, and industrially advantageous process suitable for large-scale production of telmisartan 1 has been described. The key steps include Suzuki coupling for the preparation of key intermediate 2-(4′-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 10 of telmisartan, N-alkylation, and oxazoline hydrolysis.

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What this paper is about

An improved, cost-effective, and industrially advantageous process suitable for large-scale production of telmisartan 1 has been described. The key steps include Suzuki coupling for the preparation of key intermediate 2-(4′-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 10 of telmisartan, N-alkylation, and oxazoline hydrolysis.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

An improved, cost-effective, and industrially advantageous process suitable for large-scale production of telmisartan 1 has been described. The key steps include Suzuki coupling for the preparation of key intermediate 2-(4′-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 10 of telmisartan, N-alkylation, and oxazoline hydrolysis.

Key concepts: Chemistry, Telmisartan, Oxazoline, Alkylation, Biphenyl, Hydrolysis, Combinatorial chemistry, Organic chemistry

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