Distribution and Resistance of Pathogenic Bacteria in 536 Patients of Lower Respiratory Infections

Objective: To analyse the distribution and drug resistance of the pathogenic bacteria in the patients with lower respiratory infection(LRI) and to provide the reference for rational use of the drugs. Methods: Using the software WHONET-4, to analyse the pathogenic bacteria distribution and resistance of 536 inpatients from 2008 to 2010. Results: Out of 536 inpatients with LRI, 370 strains of pathogenic bacteria were isolated. including 212 strains of Gram-negative bacteria(57.30%), 58 strains of Gram-positive bacteria(15.68%) and 100 strains of the fungi(27.02%). The detection rate of pathogenic bacteria was 52 strains of Klebsiella pneumoniae(14.05%), 43 strains of Candida albicans(11.62%), 35 strains of Acinetobacter baumannii (9.46%), 33 strains of Escherichia coli(8.92%), 23 strains of C. krusei(6.22%), 18 strains of Pseudomonas aeruginosa(4.86%), 18 strains of Aspergillus(4.86%), and 16 strains of Streptococcus pneumoniae(4.32%) respectively.Anti-microbial susceptibility showed that pathogenic bacteria were drug resistant to many antibiotics,but were sensitive to amoxicillin/clavulanic acid, piperacillin/tazobactam, amikacin and imipenem. Conclusion: The main pathogens in LRI were Gram-negative bacilli and had high resistance to the common anti-microbial agents