The value of cerebral perfusion imaging on multi-slice spiral CT in diagnosing acute cerebral infarction

Objective To explore the early diagnostic value of multi-slice CT(MSCT)cerebral perfusion imaging in acute cerebral infarction.Methods Conventional CT and CT perfusion imaging were performed in 34 patients with diagnosed clinically acute cerebral infarction.The time to peak(TTP),cerebral blood flow(CBF)and cerebral blood volume(CBV) were evaluated.All patients were counterchecked by regular CT in 3～7days.And 20 normal volunteers were enrolled as control.Results In 34cases,15 cases were diagnosed as cerebral infarction obtained regular CT positive results.In 19 having regular CT negative results,17 had cerebral infarction,and the other 2 had transient ischemic attack(TIA).32 cases were confirmed by CTP as having ischemic lesions,whose cerebral blood flow(rCBF),time to peak(rTTP)in 32 cases with CTP positive were found obviously changed.The side of ischemic lesion as compared with the opposite,and the core of ischemic lesion as compared with peripheral zone were found changed significantly(P 0.01).In the present series of 34patients,routine CT scan had sensitivity of 44.11% and specificity of 71.42%.CTP had sensitivity of 94.11% and specificity of 100%.Conclusion CTP can be used in diagnosis of early stage of acute cerebral infarction.The quantitative evaluation can differentiate the core of infarction from ischemic penumbra.It can provide valuable information for doctor to choose suitable therapy project.