2007•Journal of environmental healthRequires access
Effect of Vanadium on Antioxidase Activity in Liver Microsome and Mitochondrion of Rats
Chen He-bang
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Abstract
Objective To study the effect of vanadium on antioxidase activity in liver microsome and mitochondrion of rats. Methods 40 Wistar rats were randomly divided into 7 groups, 6 experimental groups, 1 control group. The rats in experimental groups were treated with ammonium metavanadate through drinking water at the doses of 1.25, 2.5, 5, 10, 20 and 40 mg/kg respectively for 20 consecutive days. The rats in control group were treated with distilled water. GSH-Px, CAT activity in liver microsome and SOD activity, MDA content in liver mitochondrion were determined. Results GSH-Px, CAT, SOD activity decreased and MDA content increased as ammonium metavanadate dosage increased. Compared with the control group, GSH-Px and CAT activity in 5, 10, 20 and 40 mg/kg groups decreased significantly(P0.01), SOD activity decreased significantly(P0.05) in 10, 20 and 40 mg/kg groups, MDA content increased significantly(P0.05) in 10, 20 and 40 mg/kg groups. Conclusion Vanadium can cause the antioxidase activity decrease in liver microsome and mitochondrion of rats at the exposure doses of 5-40 mg/kg.