Detection and Significance of Fas Phenotype,FasL in Hepatocelluar Carcinoma

Objective To investigate the expression level of FasL,Fas in hepatocellular carcinoma(HCC) and their relation with HCC development and prognosis.Methods The expression level of FasL and Fas in 31 HCC tissues were detected by immunohistochemical technique(S P).Results The expression rate of FasL in 31 HCC tissues was 74.2%,different from that in control( P 0.05),Fas expression rate was 51.6% in HCC,different from that of control,but there was no statistical significance( P 0.05).In majority of non cancerous specimens,Fas expression was on the surface and in the cytoplasm,whereas in majority of HCC,Fas expression was only in the cytoplasm.Meanwhile,the expression rate of FasL in HCC with metastasis was 85.7%,markly higher than those in non metastasis;on the contrary,Fas expression rate(33.3%) in HCC with metastasis was apparently lower than those( 90.0% ) in non metastasis( P 0.01).Conclusion The abnormal expression of Fas,FasL in HCC may play an important role in develpment and prognosis of HCC.