Expressions of Fas.FasL and their significance in hepatocellular carcinoma

Objective To inquired into the relationship between the expressions of Fas, FasL and pathological and clinical features of hepatocellular carcinoma(HCC) .Methods Fas and FasL were detected by observing the immunohistochemical staining of 41 specimens of HCC. Results The positive expression rates of Fas and FasL in HCC were 31.7% and 41.5%, respectively, while those in paracancerous cirrhosis tissue were 80.0 % and 65.0%,respectively.The expression rate of Fas in HCC was less than that in paracancerous tissue significantly, whereas the expression rate of FasL in paracancerous tissue was the same as in HCC. The expression of Fas and FasL had no relationship with sex,HCC size,and grade.The expression of Fas was negatively correlated with incidence of cancerous emboli in portal vein, whereas FasL expression was not associated with the latter. Conclusion These results implicate that the expression of Fas/FasL play an important role in cancerous tumor evasion, and Fas is worthy of further research on cancerous emboli in portal vein of HCC.