Isolation and Drug Resistance Situations of Escherichia coli from Urine Specimens in 2002-2007

OBJECTIVE To understand the clinical isolation and drug resistance situations of Escherichia coli from urine specimen in our hospital and provide some reference for the prevention and treatment of urinary infections.METHODS To carry out experiments on bacteria growth from the urine specimen and drug resistance,the WHOENT5 software system were used to analyze the hospital′s urine specimens on E.coli in 2002-2007.RESULTS Seventeen drugs were used to test the drug resistance of the 631 clinical samples of E.coli.The result showed that E.coli had a low drug resistance towards imipenem(3.5%),but high drug resistance to ampicillin(89.7%).The drugs that higher resistance than 50.0% included: ampicillin/sulbactam(80.5%);aztreonam(64.3%);ceftriaxone(65.1%);ceftazidime(57.4%);cefotaxime/trimethoprim(65.1%);cefazolin(72.1%);ciprofloxacin,gentamicin,tobramycin;sulfamethoxazole and cefepime(50.0%).ESBLs isolates reached up 63.5%.CONCLUSIONS E.coli has a high detection rate and serious drug resistance in urinary infections.Conventional ESBLs tests can help to appropriate use antibiotics and lower the occurrence of drug resistance.Clinical doctors are advised to restrict the usage of antibiotics in order to lower the occurrence of drug resistance strains,as well as to prevent the spread of ESBLs.