Analysis on clinical distribution and drug resistance of Escherichia coli from urine specimens in Affiliated Hospital of Inner Mongolia Medical University during 2011-2013

Objective To investigate the distribution of Escherichia coli from urine specimen and its drug resistance in Affiliated Hospital of Inner Mongolia Medical University, and to provide the reference for the prevention and treatment of urinary infections. Methods The clinical data and drug resistance of 968 strains of E. coli isolated from urine specimens from 2010 to 2013 were reviewed retrospectively. Results The 968 strains of E. coli were isolated from urine samples, there were 508 strains producing ESBLs, and the detection rates of ESBLs accounted for 35.7%, 48.5%, and 66.0%, respectively. The average of detection rates in three years was 52.6%. The drug resistance rate of E. coli to imipenem was the lowest, followed by cefoperazone/sulbactam, piperacillin /tazobactam, amikacin, and ampicillin/sulbactam. E. coli kept high resistance to other antibiotics, and the average resistance rates was higher than 50% in three years and increased year by year. The top three departments of isolation rate were nephrology, urology, and neurology, accounting for 40.6%, 29.1%, and 18.0%, respectively. Conclusion The drug resistance of E. coli from urine samples is serious. Conventional ESBLs test contributes to appropriate the usage of antibiotics and lower the occurrence of drug resistance. Clinicians should pay attention to drug susceptibility results and rational drug usage, which can prevent the spread of ESBLs strains.