Comparison of Recombinant Human Luteinizing Hormone and Human Menopausal Gonadotropin in IVF-ET

Objective:To compare IVF outcomes of the controlled ovarian stimulation(COS) protocols with r-FSH plus recombinant LH(Luveris) versus r-FSH plus HMG(Le BaoDe).Methods:The outcomes of 281 infertile normogonadotropic patients undergoing IVF/ICSI treatment were retrospectively analyzed from Feburary to November in 2011 in our center.Patients were divided into two groups according to the addition of different exogenous luteinizing hormone preparation in COS:the HMG group(n=100) and the r-hLH group(n= 181).Numbers of oocytes retrieved and fertilized,and the high quality embryos rate,as well as thickness of endometrium on the day of hCG administration,incidence of OHSS and clinical pregnancy rate,were compared as the main parameters of outcomes.Results:Duration of ovarian stimulation of the HMG group was shorter than that of the r-hLH group(P=0.049).The mean level of serum E2 on the day of hCG administration of the HMG group was statistically higher than that of the r-hLH group(P=0.033).The incidence of OHSS in the HMG group was much higher than that in the r-hLH group(P=0.016).Higher fertilization rate was found in the HMG group(P=0.000).There existed no significant differences between two groups in the total FSH consumption,thickness of endometrium on the day of hCG administration,the number of oocytes retrieved,embryo cleaved rate,high quality embryos rate,implantation rate and clinical pregnancy rate(P 0.05).Conclusions:Compared with HMG,r-hLH may lead to better IVF outcomes in safety and efficiency,and lower risk of OHSS.