2014•Liaoning zhongyi zazhiRequires access
Randomized Parallel Group Study on Impact of Benefiting Qi and Strengthening Spleen and Anti-Colorectal Cancer Herbs on Protein Kinase C and Tumor Epidermal Growth Factor and Vascular Endothelial Growth Factor Expressions
Wang Nin
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Abstract
Objective: Benefiting Qi and strengthening spleen and anti- colorectal cancer herbs on protein kinase C( PKC) and tumor epidermal growth factor( EGF),vascular endothelial growth factor( VEGF) expressions. Methods: Random parallel control method was used. 40 SD mice were randomly divided into normal group,model group,benefiting Qi and strengthening spleen group,benefiting Qi and strengthening spleen and anti- colorectal cancer group,n = 10. The normal saline was given fro model and normal groups. Benefiting Qi and strengthening spleen group and benefiting Qi and strengthening spleen and anti-colorectal cancer group were given corresponding herbs. The treatment course was 14 d. The PKC,EGF,VEGF expressions were observed to determine the efficacy. Results: After intervention for 14 days,PKC expression in normal group were higher than that in the other groups( P 0. 01) and that of normal and benefiting Qi and strengthening spleen and anti- colorectal cancer group was both higher than that of benefiting Qi and strengthening spleen group( P 0. 01). The PKC expression in benefiting Qi and strengthening spleen and anti- colorectal cancer group was higher than that of benefiting Qi and strengthening spleen group( P 0. 05) and that of benefiting Qi and strengthening spleen group Qi was higher than that of model group( P 0. 05). The apoptosis in benefiting Qi and strengthening spleen and anti- colorectal cancer group,benefiting Qi and strengthening spleen group and model group was all higher than that of model group( P 0. 01) and that of benefiting Qi and strengthening spleen and anti-colorectal cancer group was higher than that of benefiting Qi and strengthening spleen group( P 0. 01). Conclusion: The benefiting Qi and strengthening spleen herbs can improve spleen function as well as relieve the inhibition of PKC and there is more obvious effect when combined with anti- cancer herbs,effectively improving the apoptosis as well as inhibiting EGF and VEGF expressions.