2004•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Effects of xingnaojing injection on experimental dementia induced by ethanol

Zhou Hong

Abstract

AIM: To observe the effects of xingnaojing (Xnji) injection on learning and memory disorder induced by ethanol. METHODS: The memory impairment was induced by ig ethanol in mice or rats only one time or continuously for 30 days. The Morris water maze, Y maze, and step through methods were used to test the function of learning and memory. RESULTS: Xnji (14,7 ml·kg -1 ) could prevent the impairments of spatial learning ability induced by ethanol given only one time in rats; Xnji (1,2 ml·kg -1 ) could promote spatial learning ability and memory acquisition impaired by ethanol given continuously in mice. CONCLUSION: Xnji can prevent and treat the memory disorder in acute and chronic ethanol intoxication.

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Key concepts: Ethanol, Morris water navigation task, Spatial learning, Memory impairment, Dementia, Anesthesia, Medicine, Memory disorder