Expression of Survivin in Human Epithelial Ovarian Carcinoma and Its Correlation to Cyclooxygenase 2

Objective:To investigate the expression and relationship of cyclooxygenase 2 and Survivin in the patients with human epithelial ovarian carcinoma. Methods:The expressions of Survivin and COX-2 were detected with the Elivision immunohistochemical method in 60 cases of epithelial ovarian cancer, and compared with that in 20 cases of borderline cancer, 20 cases of benign tumors and 20 cases of normal tissue. Results:The expression of Survivin increased progressively from normal and benign tumors and borderline carcinoma to epithelial ovarian carcinoma (0%, 20.0%, 65.0%, and 71.7%) with significant difference (P0.05). The expression of COX-2 increased progressively from normal and benign tumors and borderline carcinoma to epithelial ovarian carcinoma (0%,0%,55.0% and 65.0%) with significant difference (P0.05). Expressions of COX-2 and Survivin protein were significant positively associated with epithelial ovarian carcinoma tissues(liner index of Pearson=0.978,P0.001). Conclusions: The overexpression of COX-2 and Survivin protein may play an role in pathogenesis of ovarian cancer. Expressions of COX-2 and Survivin protein were significant positively associated with epithelial ovarian carcinoma tissues. It is speculated that there maybe a common transcription mechanism which constructed multiple pathways contributing to the inhibition of apoptosis in human epithelial ovarian carcinoma.