Effect of Limai Capsule on the Learning and Memory Ability of Mice

Objective To observe the effect of Limai capsule on learning and memory defict induced by scopolamine and spatial memory ability of normal mice.Methods The step-down test and Morris water maze were adopted to observe the effect of Limai capsule(140 mg/kg,ig) on the learning and memory defict induced by scopolamine and spatial memory ability of normal mice respectively.Results ①On the first training day,the error times of Limai capsule group were less than those in model group within 3 minutes(P0.01).No significant difference was found between Limai capsule group and nomal group(P0.05).On the second detected day,the electrical injury latency in model group was less than that in normal group.Compared with model group,Limai capsule could significantly prolong the electrical injury latency and was close to the normal one(P0.01).②Compared with normal group,Limai capsule could significantly decrease the escape latency of normal mice but had no effect on the number of passing through primary flat place in Morris water maze test.Conclusion Limai capsule can improve learning and memory defict induced by scopolamine and has effect on intelligence increase.