Stuey on significance of serum levels of intercellular adhesion molecule-1 in patients with lung cancer

Objective To evaluate the significance of serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with lung cancer.Methods Serum levels of sICAM-1 in 22 cases were sequentially determined by ELISA.Results Before chemotherapy,the serum levels of sICAM-1 in patients with lung cancer were significantly higher than those in the controls [(348.4±101.7)mg/L vs(171.3±34.2)mg/L,P0.01] and the serum levels of sICAM-1 were significantly correlated with the size of the primary tumor of the lung (r=0.6014,P0.01).The survival rate of the group of sICAM-1300 mg/L was significantly lower than that of the group of sICAM-1300 mg/L(26.7% vs 85.7%,P0.05).The serum levels of sICAM-1 of 2 weeks after chemotherapy significantly decreased when the therapy was effective [(248.6±46.7)mg/L vs (377.4±48.7)mg/L,P0.01],but they kept to the level when the therapy was ineffective [(330.9±130.4)mg/L vs (324.3±128.1)mg/L,(P0.05].Conclusion The serum levels of sICAM-1 in patients with lung cancer are correlated with the tumor burden and clinical stage as well as the histological type of the cancer.The serum levels of sICAM-1 could be used as one of the measures to evaluate the therapeutic efficacy and to prognosticate the patients.