Clinical significance of serum soluble of intercellular adhesion molecule-1 in the plasma of the patients with breast cancer

Objective To evaluate clinical significance of the serum soluble intercellular adhesion molecule-1 and SE-selectin in the plasma of the patients with breast cancer. Methods The SE-selectin and SICAM-1 levels were tested in 30 patients with breast cancer (treatment group), 15 patients with postoperative recurrence (recurrence group) and 20 normal control cases by enzyme linked immunosorbent assay (ELISA) technique. Results The SE-selectin, SICAM-1 levels in patients with breast cancer treatment group were higher than those of normal ones significantly ( P0.01). The SE-selectin, SICAM-1 levels decreased at 15 days after operation, but their levels were still higher than the normal ones (P0.05),and their levels decreased to the normal ones at 30 days after operation(P0.05). The SE-selectin, SICAM-1 levels in patients recurrence after operation were higher than those of normal ones significantly too( P0.01).The SE-selectin and SICAM-1 levels in patients with breast cancer were correlated with the metastasis of lymph node and the clinical stage (P0.01), yet their levels had no relation to the age, tumor size and histological grades (P0.05). Conclusion The SE-selectin and SICAM-1 levels possiblely have important significance to diagnosis early and estimate the effect of operation and detecte recurrence after operation in patients with breast cancer.