CORRELATION STUDY ON THE RELATIONSHIP BETWEEN CT PERFUSION IMAGING AND ANGIOGENESIS OF GLIOMA

[Objective]To discuss the relationship between the CT perfusion parameters and MVD for a safe and reliable preoperative diagnosis to grade and prognosticate the brain glioma.[Methods]Twenty hospitalized untreated glioma patients primarily diagnosed by CT or MR were selected.CT Perfusion technique was performed.CBF,CBV,PS value were measured in the interested areas and corresponding normal areas and the perfusion images were obtained.After surgical resection of the tumor,HE stain was carried out in order to confirm pathological type of interested areas.MVD was detected by immunohistochemical SP staining.SPSS14.0 was used for statistical analysis.One-way ANOVA and SNK-test were applied for perfusion parameters of all groups.Pearson corelation analysis were carried out between perfusion parameters and MVD of the low grade group and the high grade group.[Results](1)The CBF values of the control group,low grade group and high grade group were 22.11±3.23,0.72±0.10,0.81±0.07 respectively.The CBV values were 50.28±10.90,2.26±0.49,4.99±1.01 respectively and the PS values were 107.95±15.87,6.35±1.05,11.28±1.76 respectively.F values were 199.6,170.16,209.46 respectively.P values were 0.00,0.00,0.00 respectively.P value was less than 0.01 by SNK-test among each group.(2)Low and high grade glioma MVD were 31.00±8.47,60.60±7.96 respectively.(3)CBF,CBV,PS value of low and high grade glioma and tumor MVD presented positive correlation with statistical processing.Correlation coefficient value were 0.79,0.85 and 0.77 respectively and P value was less than 0.01.[Conclusion]Rapid and noninvasive CT perfusion imaging technique can accurately reflect the perfusion status of the tumor tissue and estimate proliferation state of tumor vessels.It provides a safe and reliable method for preoperative diagnosis,grading and prognosis judgment of brain glioma.