2006•Jiepou kexue jinzhanRequires access

Arsenic Trioxide Induces Apoptosis in Ovarian Cancer Cell Line HO8910

Gao Hong-quan

Abstract

Objective The current study was designed to investigate the effect of arsenic trioxide(As_(2)O_(3)) on induction of apoptosis in ovarian cancer cell.Methods Cell proliferation was assessed by MTT assays,morphological changes of apoptosis were observed with invert microscope and transmission electron microscope.DNA ladder and cell cycle were examined by DNA agarose gel eletronphores and PI fluorescence flow cytometry(FCM)respectively.Results Under the influence of arsenic trioxide,HO8910 cell exhibited changes of apoptosis both in morphology and in the characteristics of electrophoresis.Meanwhile the cell cycle also showed special change with the apperance of G1 peak and increase of S+G2~M cells.Conclusion Arsenic trioxide inhibits cell proliferation,induces apoptosis in ovarian cancer cell.

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Key concepts: Arsenic trioxide, Apoptosis, Cell cycle, Flow cytometry, Agarose gel electrophoresis, Chemistry, Cell growth, Cell