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Influence of inhaling gentamycin via aerosol on the phagocytosis function of alveolar macrophage in lungs of rats with severe head injury

Zhu Jing-c

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Abstract

Objective To study the influence of inhaling gentamycin via aerosol on the phagocytosis function of AM in the lungs of rats with severe head injury. Methods The model of severe head injury (SHI) was established by local impact injury. 40 male SD rats were divided randomly into normal group (NG, n=4), control group (CG, n=18) and experimental group (EG, n=18). Patients in the control group inhaled normal saline via aerosol, and in the experimental group inhaled gentamycin via aerosol after injury. The phagocytosis function of AM was investigated by Oidium albicans. Results The phagocytosis percentage of EG(0.415±0.089) were markedly lower than that of CG (0.560± 0.075) on day 7, P0.001. Conclusions Long-term administration of gentamycin via aerosol can obviously reduce the phagocytosis percentage of AM in the lungs of rats with severe head injury.

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What this paper is about

Objective To study the influence of inhaling gentamycin via aerosol on the phagocytosis function of AM in the lungs of rats with severe head injury. Methods The model of severe head injury (SHI) was established by local impact injury. 40 male SD rats were divided randomly into normal group (NG, n=4), control group (CG, n=18) and experimental group (EG, n=18). Patients in the control group inhaled normal saline via aerosol, and in the experimental group inhaled gentamycin via aerosol after injury. The phagocytosis function of AM was investigated by Oidium albicans. Results The phagocytosis percentage of EG(0.415±0.089) were markedly lower than that of CG (0.560± 0.075) on day 7, P0.001. Conclusions Long-term administration of gentamycin via aerosol can obviously reduce the phagocytosis percentage of AM in the lungs of rats with severe head injury.

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Available abstract

Objective To study the influence of inhaling gentamycin via aerosol on the phagocytosis function of AM in the lungs of rats with severe head injury. Methods The model of severe head injury (SHI) was established by local impact injury. 40 male SD rats were divided randomly into normal group (NG, n=4), control group (CG, n=18) and experimental group (EG, n=18). Patients in the control group inhaled normal saline via aerosol, and in the experimental group inhaled gentamycin via aerosol after injury. The phagocytosis function of AM was investigated by Oidium albicans. Results The phagocytosis percentage of EG(0.415±0.089) were markedly lower than that of CG (0.560± 0.075) on day 7, P0.001. Conclusions Long-term administration of gentamycin via aerosol can obviously reduce the phagocytosis percentage of AM in the lungs of rats with severe head injury.

Key concepts: Phagocytosis, Medicine, Saline, Aerosol, Candida albicans, Alveolar macrophage, Head injury, Anesthesia

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