Effect of aerosolized inhaling of γ-interferon on the level of TNF-α and IL-6 in BALF after lung injury secondary to severe head injury in rats

Objective To study the effects of aerosolized inhaling of γ-Interferon(γ-IFN) on the level of TNF-α and IL-6 in BALF after lung injury secondary to severe head injury in rats.Methods The models of severe head injury was established by local impact injury.Sixty-four male SD rats were divided randomly into normal group(N) and trauma group(T),and then,the T group was divided into control group(C),gentamycin group(Gen) and γ-Interferon group(γ-IFN).Normal saline was inhaled in the rats of the group C.Normal saline plus gentamycin was inhaled in group Gen.Normal saline plus γ-IFN was inhaled in group γ-IFN.The level of TNF-α and IL6 in BALF were investigated among different groups.Results The level of TNF-α on 1,3d and IL-6 on 3d were significant lower than that of group C and Gen,while the level of IL-6 on 7d was significant higher than that of group C and Gen.Conclusion Administration of γ-Interferon via aerosol can reduce the level of TNF-α and IL-6 in BALF of SHI rats during the first 3 days after injury.