Clinical study on relationship between complement3 and high-sensitivity c-reactive protein in acute ischemic cerebral disease

Objective:To study dynamically the relativity of the change of serum complement3(C3),high-sensitivity C-reactive protein(Hs-CRP),infarct volume and neurological impairment within half month after the patients suffering from acute ischemic cerebrovascular disease(cerebral infarction).Methods:The content of Serum C3 and Hs-CRP level of 40 cerebral infarction patients and 30 Healthy Volunteers as comparation was detected by Nephelometry after the 12h,24h,48h,72h,7d and 15d.To observe and record the score of case about infarct volume and neurological impairment.Results:The levels of serum C3 and Hs-CRP in patients with cerebral infarction were higher significantly than that in the normal Controls after the 12h,24h,48h,72h,7d and 15d(P0.05),but it had no significant differences between the two groups after 15 days(P 0.05).The levels of serum C3 and Hs-CRP in patients with cerebral infarction were correlated with infarct volume,the bigger the infarct volume,the higher the levels of serum C3 and Hs-CRP.The levels of serum C3 and Hs-CRP in the large-focus group and middle-focus group with cerebral infarction were higher significantly than that in the small-focus group with cerebral infarction(P0.05).The levels of serum C3 and Hs-CRP in patients with cerebral infarction were correlated with neurological impairment,the more serious the neurological impairment,the higher the levels of serum C3 and Hs-CRP.The levels of serum C3 and Hs-CRP in the severe group and the moderate group with neurological impairment were higher significantly than that in the mild group with neurological impairment(P0.05).Conclusion:The levels of serum C3 and Hs-CRP in patients play a very important role in the occurrence and development of cerebral infarction.The increased levels of them have certain correlation with infarct volume and the degree of neurological impairment.