Clinical efficacy of Argatroban Injection combined with edaravone in treatment of acute ischemic cerebral infarction

Objective To explore the clinical efficacy of Argatroban Injection combined with edaravone in the treatment of acute ischemic cerebral infarction. Methods Patients(140 cases) with acute ischemic cerebral infarction,who came to Affiliated Nanjing Brain Hospital,Nanjing Medical University,from July 2012 to June 2013,were divided into control group(68 cases) and treatment group(72 cases). Patients in the two groups were given Edaravone Injection 30 mg/time,which was dissolved in saline 100 mL and was dripped completely within 30 min,twice daily. On the basis of the control group,patients in the treatment group were given Argatroban Injection 60 mg/d,which was dissolved in saline 48 mL and was iv completely within 24 h on two days before. And then they were given Argatroban Injection 10 mg/d,which was dissolved in saline 250 mL and was continuously dripped twice in the morning and evening,3 h/time,for 7 d. The patients accepted the treatment for 14 d. The hemodynamics,blood coagulation,and quality of life indexes in the two groups were compared. Results After the treatment,the hemodynamic indexes in the two groups were lower than those before the treatment with significant difference(P 0.05). And the hemodynamic indexes in the treatment group were lower than those in the control group with significant difference(P 0.05). After the treatment,the blood coagulation and quality of life indexes in the two groups were improved compared with those before the treatment. And the blood coagulation and quality of life indexes in the treatment group were better than those in the control group with significant difference(P 0.05). Conclusion Argatroban Injection combined with edaravone in the treatment of acute ischemic cerebral infarction has a good clinical efficacy,which is worthy of clinical application.