Observation of efficacy and safety on Argatroban Injection in treatment of patients with acute cerebral infarction

Objective To evaluate the efficacy and safety of Argatroban Injection in the treatment of the patients with acute cerebral infarction.Methods The patients(60 cases) diagnosed as acutecerebral infarction in Chinese PLA 254 Hospital from December 2010 to December 2012 were randomly divided into treatment(30 cases) and control(30 cases) groups.The two groups were given the treatment to reduce blood fat,and control blood pressure and sugar.In addition,the patients in the control group was po administered with Aspirin,1 pill/time,once daily.The treatment group was treated with Argatroban Injection(60 mg diluted with 500 mL physiological saline) through 24 h continuous iv pump infusion on the first 2 d.The next 5 d they were treated with Argatroban Injection(10 mg diluted with 250 mL physiological saline),through continuous 3 h iv infusion twice daily in the morning and evening.The patients in the two groups were treated for 7 d.NIHSS scoring and adverse reactions were observed and evaluated after the treatment for 7 d and 14 d,at the same time.Results Within 7 d and 14 d after the treatment,the NIHSS scores of the patient in the two groups were significantly lower than those before the treatment(P 0.05),and the difference between the two groups was statistically significant(P 0.05).The efficiency for the patients both in the treatment and control groups were 93.3% and 76.7% with the significant difference(P 0.05).There was no adverse reaction in the two groups.Conclusion Argatroban Injection has an accurate curative effect on the progressive cerebral infarction,but has no adverse reaction.