Clinical research of Jianpi Yifei Decoction on treating COPD patients of lung-spleen qi deficiency who need non-invasive mechanical ventilation

Objective To observe the efficacy of adopting strengthening spleen and tonifying lung method by using JPYF decoction,to improve the muscle strength of COPD patients' who need non-invasive mechanical ventilation to release their respiratory muscle fatigue. Methods Subjects for this study were acute exacerbation of COPD patients who need noninvasive mechanical ventilation therapy to release symptoms of respiratory failure,and all the patients have the traditional Chinese medicine clinical features of Qi deficiency of lung and spleen. A randomized,controlled study was performed. All the patients were randomly divided into control group( standard treatment group) and treatment group( standard treatment group + JPYF decoction orally taken group). Observation was started when patient began to receive noninvasive mechanical ventilation therapy,the patient's clinical symptoms during the observation,indicators of respiratory muscle fatigue,blood gas analysis and other indicators were collected. Results The clinical symptoms in treatment group were improved by 89. 7%,and 58. 6% of the control group,the treatment group was significantly better than the control group( P 0. 01); two groups show increased PaO 2,lower PaCO 2( P 0. 05) after treatment. After treatment,the indicators of the two groups had no significant difference( P 0. 05); lung function were significantly improved after treatment( P 0. 05); MIP、MEP of treatment group were significantly increased than the control group,and compare to control group,FEV 1 % and RR can also be improved( P 0. 05). Conclusion On the basis of the conventional non-invasive ventilation,applying the method of strengthening spleen and tonifying lung,and using the experience prescription JPYF decoction can improve the clinical symptoms,relieve patients' respiratory muscle fatigue and improve respiratory failure.