ScholarLens Back to search
2007•Acta Universitatis Medicinalis NanjingRequires access

Antioxiative effects of spironolactone on rat kidney with unilateral ureteral obstruction

Ruan Yingxin

Open publisher page 0 citations

Abstract

Objective:To investigate the antioxiative effects of spironolactone,an aldosterone receptor blockade,on kidney of rats with unilateral ureteral obstruction(UUO).Methods:Thirty wistar rats underwent UUO and then received vehicle(n = 11)or spironolactone(50mg.kg-1.d-1 by daily gastric gavage,n = 12)during the 15 days from the day before surgery.Additional 7 rats were sham operated.All the rats were killed at 14 days after surgery.Histological changes were observed by HE and Masson staining.Malondialdehyde(MDA),superoxide dismutase(SOD)as well as aldosterone(ALD)content were measured.Results:UUO induced a significant increase in MDA and ALD content but a marked decrease in SOD content and severe morphology changes.However,spironolactone ameliorated what had mentioned.Conclusions:Spironolactone can suppress oxidative stress and alleviate renal in rats with UUO by reducing lipid peroxidation production and improving antioxidative enzyme contents.

About this research paper

What this paper is about

Objective:To investigate the antioxiative effects of spironolactone,an aldosterone receptor blockade,on kidney of rats with unilateral ureteral obstruction(UUO).Methods:Thirty wistar rats underwent UUO and then received vehicle(n = 11)or spironolactone(50mg.kg-1.d-1 by daily gastric gavage,n = 12)during the 15 days from the day before surgery.Additional 7 rats were sham operated.All the rats were killed at 14 days after surgery.Histological changes were observed by HE and Masson staining.Malondialdehyde(MDA),superoxide dismutase(SOD)as well as aldosterone(ALD)content were measured.Results:UUO induced a significant increase in MDA and ALD content but a marked decrease in SOD content and severe morphology changes.However,spironolactone ameliorated what had mentioned.Conclusions:Spironolactone can suppress oxidative stress and alleviate renal in rats with UUO by reducing lipid peroxidation production and improving antioxidative enzyme contents.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the antioxiative effects of spironolactone,an aldosterone receptor blockade,on kidney of rats with unilateral ureteral obstruction(UUO).Methods:Thirty wistar rats underwent UUO and then received vehicle(n = 11)or spironolactone(50mg.kg-1.d-1 by daily gastric gavage,n = 12)during the 15 days from the day before surgery.Additional 7 rats were sham operated.All the rats were killed at 14 days after surgery.Histological changes were observed by HE and Masson staining.Malondialdehyde(MDA),superoxide dismutase(SOD)as well as aldosterone(ALD)content were measured.Results:UUO induced a significant increase in MDA and ALD content but a marked decrease in SOD content and severe morphology changes.However,spironolactone ameliorated what had mentioned.Conclusions:Spironolactone can suppress oxidative stress and alleviate renal in rats with UUO by reducing lipid peroxidation production and improving antioxidative enzyme contents.

Key concepts: Spironolactone, Malondialdehyde, Lipid peroxidation, Aldosterone, Superoxide dismutase, Kidney, Endocrinology, Mineralocorticoid receptor

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Antioxiative effects of spironolactone on rat kidney with unilateral ureteral obstruction — Research Paper | ScholarLens