Protection mechanism of Edaravone pretreatment in rats with cerebral ischemia-reperfusion injury

Objective To explore the protection mechanism of Edaravone pretreatment in rats with focal cerebral ischemia-reperfusion injury. Methods Thirty-six SD rats were randomly divided into sham operation group,cerebral ischemia-reperfusion group and Edaravone group.Edaravone group was received Edaravone 60 mg/(kg·d) by gavage for 3 d before operation.Ischemia-reperfusion injury model was made by embolige the middle cerebral artery.The score of neurological defict,cerebral infarction volumes,the contents of serum neuron-specific Enolase(NSE),brain tissue interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α) were compared among each group. Results Compared with ischemic-reperfusion group,the score of neurological defict in Edaravone group was significantly decreased,cerebral infarction volume was significantly reduced,and serum NSE content was significantly decreased(all P0.01).The contants of IL-1β and TNF-α in brain tissue were significantly lower(P0.05-0.01). Conclusion Edaravone pretreatment can reduce the expression of IL-1β and TNF-α after cerebral ischemia-reperfusion injusy,and protect brain tissue.