EXPRESSION AND SIGNIFICANCE OF P73 AND P21 IN BREAST CARCINOMA

Objective: To investigate the biological features of breast carcinoma and analyze P73 and P21's functions in progression and metastasis of breast carcinoma by the examination of P73, P21 and their relationship with clinicopathological index. Methods: A total of 68 paraffin-embedded tissue of breast carcinomas were observed by the use of S-P method to examine the expression of P73, P21 proteins. Results: (1)The postive expression rate was 18.75%(9/48) and 60.00% (12/20) in grade Ⅰ-Ⅱ and grade Ⅲ of breast carcinoma respectively, with significant difference ($P$0.05). Breast tumor malignant degree increased with P73 positive expression increased. (2)The postive expression rate of P21 in the group with lymph nodes metastasis was 23.33%(7/30), that of P21 in non-lymph nodes metastasis was 52.63%(20/38). the former was lower than the latter, with significant difference (P0.05). (3)There were no significant correlations between P73 and P21. Conclusion: It revealed that P21 and P73 were correlated with the genesis and progression of breast carcinomas.