The Expression and Significance of P-GSK3β and β-catenin in Human Breast Cancer

Objective To determine the expression of P-GSK3β and β-catenin in the Human breast cancer tissue,.study their relationship with clinicopathological factor in breast cancer,and analyze their expression significance and their correlation with each other. Methods 56 cases of breast carcinoma,30 cases of adjacent nontumor normal breast tissue were detected in P-GSK3β and β-catenin by microwave EliVisionTM. Results(1)The postitive expression of P-GSK3β and the abnormal β-catenin in 56 cases of breast carcinoma were 57.14% and 64.29% respectively.There was a significant different between carcinoma and normal breast tissue(P 0.05);(2)The overexpression of P-GSK3β in breast carcinoma had no relationship with the size of primary tumor,age and pathological type,but had some relationship with histological classification,clinical TNM staging,and lymph node metastasis(P0.05);the abnormal β-catenin expression was inversely correlated with lymph node metastasis and histological classification(P0.05),had no relationship with age,size of primary tumor,clinical TNM staging and pathological type(P0.05).(3)It was positive correlation between them(P0.05). Conclusion P-GSK3β and β-catenin were highly expressed in the endometrial cancinoma and its expression was related with endometrial carcinoma development and metastasis.