Influence of Chuanxiong Extract on the contraction performance of in vitro mice uterus smooth muscle

Objective:To observe Chuanxiong Extract on the contraction performance of in vitro mice uterus smooth muscle.Methods:30 mice were randomly divided into 3 groups:high concentration group,moderate concentration group and low concentration group,with 10 mice in each group.3 days before the experiment,0.2 ml Stilbestrol were given to each group every day via subcutaneous injection.Then the mice were killed through cervical dislocation,and the uterus was tak en out and placed in culture medium,then put into pressure transducer connected with Michael's bath,continued supplying oxygen.The normal curve of the uterine contraction was recorded for 10 min,then different concentrations of Chuanxiong Extract were added,the activity curves were recorded separately after adding Chuanxiong Extract.Results:Chuanxiong Extract had an inhibitory effect on in vitro uterine smooth muscle;with the increase of concentration,the inhibitory effect was more obviously(P0.05).Conclusion:Chuanxiong Extract has a significantly inhibitory effect on uterine smooth muscle.