Relationship of C-Reactive Protein to Metabolic Syndrome in Obese Subject

Purpose To assess the association of serum C reactive protein(CRP),a sensitive systemic marker of inflammation,with metabolic syndrome in obese subjects. Methods We studied 153 obese subjects and 47 normal control subjects in Shanghai area.Obese subjects are divided into two groups according to the degree of their glucose tolerance.Their serum CRP level and anthropometrical parameters,plasm glucose,lipid,fast insulin(FIN),proinsulin(PI) were measured.We tested whether serum CRP level are associated with metabolic syndrome in obesity. Results (1) The obese subjects had higher serum CRP level than normal controls( P 0.001),there was no significant different between the obese subjects and the obese subjects with impairment of glucose metabolism ( P =0.413);(2) There was significant positive correlation bet ween serum CRP and W,WHR,SBP,TG,PI,P/I Ratio,HOMA?IR;(3) After adjusted AGE and BMI,there was positive correlation between CRP and SBP,WHR,PI yet,the correlation between serum CRP and other parameters disappeared. Conclusions (1) There was significant increase of serum CRP level in obesity.Increase of serum CRP was closely correlation with metabolic syndrome;(2) β cell impairment was possiblely association to increase of serum CRP;(3) BMI,SBP,WHR and PI were main factors relation to increase of serum CRP.