Relationships between human serum C reactive protein, glucose concentration and insulin sensitivity in obese or overweight women

C-reactive protein (CRP) as an inflammatory marker is known to be a risk marker associated with cardiovascular diseases. In this study, relationship between serum CRP with glucose and insulin sensitivity were determined in obese or overweight women. For this purpose, fasting blood samples were collected in 21 sedentary healthy obese or overweight women (age, 39 ± 5.3 year; BMI, 32 ± 3.7 kg/m2) in order to measuring serum CRP, insulin and glucose concentration. Insulin sensitivity was calculated using insulin and glucose. Pearson's correlations were performed to identify possible relationship among the assessed variables. A positive association was observed between fasting glucose and serum CRP (p = 0.027, r = 0.48). There were no correlations between serum CRP concentrations with insulin (p = 0.881, r = 0.035) or insulin sensitivity (p = 0.821, r = 0.053). Our findings indicate that circulating CRP can be affect glucose concentration independent of insulin sensitivity in obese or overweight subjects.