Cardiac biventricular resynchronization therapy of chronic refractory heart failure

Objective To appraise the therapeutic effects of resynchronous biventricular pacing on refracto-ry chronic heart failure.Methods 6 patients with chronic refractory heart failure accompanied by intraventricular conduction delay were selected to receive resynchronous biventricular pacing.Changes of NYHA functional class,QRS duration,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),mitral re-gurgitation(MR)and 6 minutes walk distance(6MWD)were observed before and 3,6 months after implantation.Re-sults Three and sixmonths after implantation,NYHA functional class was obviously improved to 2.6 ±0.5 and 2.2±0.6 from 3.7±0.5.QRS duration was obviously decreased to 120.2±21.4 ms and 118.6±20.2ms from150.8± 21.5ms.LVEF was obviously increased to 0.46±0.08 and 0.51±0.10 from 0.28±0.06.LVEDD was decreased to 64.6±8.1mm and 61.8 ±10.2mm(P0.05) from 70.5±8.3mm.MR was obviously decreased to 16.7 ±8.7ml and 10.9 ±9.2ml from 27.8 ±13.6 ml.Six MWD was obviously increased to 326.8±112.4m and 440.2±172.1m from 170.6 ±123.7m(P 0.05).Conclusion Resynchronous biventricular pacing can improve hemodynamics,cardiac function,clinical symptoms and quality of life in patients with chronic refractory heart failure.