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Determination of Ginsenoside Rg_1 and Rb_1 in Stasis-dissolving Capsule by HPLC

Chunxin Li

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Abstract

HPLC is adopted to establish a method to determine the content of Ginsenoside Rg1 and Ginsenoside Rb1 in stasis-dissolving capsule. The system consists of NH2 column while acetonitrile -water(77∶23)is a mobile phase with a flow rate of 1.0 ml min and the UV detection wavelength is 203 nm. A good linear correlation has been found in HPLC. As for ginsenoside Rg1, the average recovery is 100.63 %, RSD is 0.87 % (n=6) , and the linear range is 0.050 3～0.502 6 mg·mL (r= 0.999 9); as for ginsenoside Rg2, the average recovery is 98.13 %, RSD is 1.25 % (n=6) , and the linear range is 0.050 4～0.504 0 mg·mL(r=0.999 6).The paper comes to the conclusion that this method is accurate and can be used for quality control of the stasis-dissolving capsule.

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What this paper is about

HPLC is adopted to establish a method to determine the content of Ginsenoside Rg1 and Ginsenoside Rb1 in stasis-dissolving capsule. The system consists of NH2 column while acetonitrile -water(77∶23)is a mobile phase with a flow rate of 1.0 ml min and the UV detection wavelength is 203 nm. A good linear correlation has been found in HPLC. As for ginsenoside Rg1, the average recovery is 100.63 %, RSD is 0.87 % (n=6) , and the linear range is 0.050 3～0.502 6 mg·mL (r= 0.999 9); as for ginsenoside Rg2, the average recovery is 98.13 %, RSD is 1.25 % (n=6) , and the linear range is 0.050 4～0.504 0 mg·mL(r=0.999 6).The paper comes to the conclusion that this method is accurate and can be used for quality control of the stasis-dissolving capsule.

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Available abstract

HPLC is adopted to establish a method to determine the content of Ginsenoside Rg1 and Ginsenoside Rb1 in stasis-dissolving capsule. The system consists of NH2 column while acetonitrile -water(77∶23)is a mobile phase with a flow rate of 1.0 ml min and the UV detection wavelength is 203 nm. A good linear correlation has been found in HPLC. As for ginsenoside Rg1, the average recovery is 100.63 %, RSD is 0.87 % (n=6) , and the linear range is 0.050 3～0.502 6 mg·mL (r= 0.999 9); as for ginsenoside Rg2, the average recovery is 98.13 %, RSD is 1.25 % (n=6) , and the linear range is 0.050 4～0.504 0 mg·mL(r=0.999 6).The paper comes to the conclusion that this method is accurate and can be used for quality control of the stasis-dissolving capsule.

Key concepts: Capsule, Chromatography, Ginsenoside, Linear range, High-performance liquid chromatography, Ginsenoside Rg1, Dissolution, Chemistry

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