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2007•China Practical MedicineRequires access

Detemination of ginsenoside Rg_1,ginsenoside Rb_1 In xunhuankang Capsules by HPLC

Yan Qian-lin

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Abstract

Objective To establish an HPLC method for the determination of ginsenoside Rg1,ginsenosigeRb1 in xunhuankang Capsulese.Methods An HPLC method was applied with a Shim-pack VP-ODS-C18(150×4.6 mm,5m)column by a gradient elution using (A)acetonitrile-(B)water as the mobile phase 0 min(20%A)→15 min (40%A) →20 min(20%A) →25 min(20%A).The flow rate was 1.0ml·min-1.The column temperature was 30℃ and the UV detection wavelength was203nm.Results The linearity range of ginsenoside Rg1and ginsenosigeRb1 is 2.45～12.25 g、2.65～13.25 g.the recovery of ginsenoside Rg196.1%,ginsenosigeRb194.9%,and RSD is 2.0%,1.8%.Conclusion This method is simple,exact,leliable and precise.It is used to measure /determine the content of xunhuanKang Capsulese Oral Solusion.

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Objective To establish an HPLC method for the determination of ginsenoside Rg1,ginsenosigeRb1 in xunhuankang Capsulese.Methods An HPLC method was applied with a Shim-pack VP-ODS-C18(150×4.6 mm,5m)column by a gradient elution using (A)acetonitrile-(B)water as the mobile phase 0 min(20%A)→15 min (40%A) →20 min(20%A) →25 min(20%A).The flow rate was 1.0ml·min-1.The column temperature was 30℃ and the UV detection wavelength was203nm.Results The linearity range of ginsenoside Rg1and ginsenosigeRb1 is 2.45～12.25 g、2.65～13.25 g.the recovery of ginsenoside Rg196.1%,ginsenosigeRb194.9%,and RSD is 2.0%,1.8%.Conclusion This method is simple,exact,leliable and precise.It is used to measure /determine the content of xunhuanKang Capsulese Oral Solusion.

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Available abstract

Objective To establish an HPLC method for the determination of ginsenoside Rg1,ginsenosigeRb1 in xunhuankang Capsulese.Methods An HPLC method was applied with a Shim-pack VP-ODS-C18(150×4.6 mm,5m)column by a gradient elution using (A)acetonitrile-(B)water as the mobile phase 0 min(20%A)→15 min (40%A) →20 min(20%A) →25 min(20%A).The flow rate was 1.0ml·min-1.The column temperature was 30℃ and the UV detection wavelength was203nm.Results The linearity range of ginsenoside Rg1and ginsenosigeRb1 is 2.45～12.25 g、2.65～13.25 g.the recovery of ginsenoside Rg196.1%,ginsenosigeRb194.9%,and RSD is 2.0%,1.8%.Conclusion This method is simple,exact,leliable and precise.It is used to measure /determine the content of xunhuanKang Capsulese Oral Solusion.

Key concepts: Chromatography, High-performance liquid chromatography, Medicine, Ginsenoside, Gradient elution, Ginsenoside Rg1, Content determination, Ginseng

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