Effects of aspirin on inflammatory factors of type 2 diabetes mellitus patients

AIM To observe the changes of serum high-sensitivity C-reactive protein(hs-CRP),interleukin 6(IL-6),and tumor necrosis factor α(TNF-α) level in patients with type 2 diabetes mellitus(T2DM) after orally taking aspirin.METHODS Eighty-two T2DM patients were divided into trial group and control group.They were treated by normalization of blood glucose and decrease of blood pressure for one year.Aspirin 100 mg·d-1 was given additionally to patients in the trial group during the same period.The levels of fasting blood glucose(FBG),fasting insulin(FINS),hemoglobin A1c(HbA1c),hs-CRP,IL-6 and TNF-α of T2DM patients in the treated group and the control group were measured before and one year after the treatment.RESULTS By the end of one year,the levels of FBG and HbA1c decreased in both groups with significant difference than before(P 0.01),and FBG in the trial group decreased more obviously than that in the control group(P 0.01).The levels of FINS and insulin resistant index also decreased in the trial group,while those in the control group did not change significantly,showing significant difference between the two groups(P 0.01).The serum levels of hs-CRP,IL-6 and TNF-α decreased(1.2 ± s 0.4) mg·L-1,(6 ± 4) ng·L-1 and(6 ± 7) ng·L-1 in the trial group versus(0.13 ± 0.05) mg·L-1,(0.02 ± 0.13) ng·L-1 and(1.3 ± 1.0) ng·L-1 decreased in the control group respectively,showing significant more decrease of those in the trial group(P 0.01).The adverse reactions after taking aspirin were nausea and upper abdominal upset for just two patients with stop aspirin intake in one.CONCLUSION T2DM patients treated by aspirin could decrease the inflammatory factors and thus the anti-inflammation is a choice for preventing and treating patients with T2DM.