Analysis on clinical effect of surgical operation in treatment of patients with type 2 diabetes mellitus

Objective To explore the clinical effect and safety of surgical operation in treatment of patients with type 2 diabetes mellitus( T2DM). Methods Two hundred patients with T2 DM were randomly divided into two groups,100 cases in each group. Patients in control group were given with injection of insulin,whereas patients in trial group were treated by laparoscopic surgery or laparotomy. The body mass index( BMI),changes of DM- related indexes and blood lipids as well as the occurrence of complications were observed before and after treatment,and the clinical effects of two groups were also compared. Results The total effective rate of trial group was significantly higher than that of control group,and the difference was statistically significant( P 0. 01). After treatment,the levels of fasting blood glucose( FBG),2 h postprandial blood glucose( 2 hPBG),C peptide and glycosylated hemoglobin( HbA1c) and BMI were obviously decreased in comparison with those before treatment( P 0. 05 or P 0. 01),and levels of FBG and 2 hPBG and BMI in trial group were significantly lower than those of control group,and the difference was statistically significant( P 0. 05 or P 0. 01). After treatment,the levels of total cholesterol( TC),triglyceride( TG)and low density lipoprotein cholesterol( LDL- C) in trial group were evidently decreased in comparison with those before treatment,while TC level in control group was obviously decreased,and the above indexes in trial group were significantly lower than those of control group,and the difference was statistically significant( P 0. 05 or P 0. 01). In comparison with the incidence of complications in these two groups,the difference was not obvious( P 0. 05). Conclusion Surgical operation can effectively decrease the levels of blood glucose and lipids as well as body weight in patients with T2 DM,it is a better,safe and effective method,and it is superior to that of insulin injection.