The frequency of the Pro12Ala single nucleotide polymorphism in peroxidase proliferation of activated receptor-γ2 gene with type 2 diabetes mellitus

Objective To evaluate the frequency of Pro12Ala single nucleotide polymorphism in peroxidase proliferation of activated receptor-γ2 gene on type 2 diabetes mellitus in Inner Mongolia Han ethnic group. Methods Selected 152 cases of subjects according to WHO criteria for diagnosis of mellitus and according to BMI in type 2 diabetes mellitus(n=97) and 55 cases as the control. These subjects were evaluated for the Pro12Ala single nucleotide polymorphism in the PPARγ2 using Taqman probe in real-time Q-PCR. Results The distribution of genotype and allele frequency of PPARγ2 Pro12Ala in accordance with H-W genetic equilibrium(χ2 =0.021, P=0.885). There were given priority to with PP genotype between diabetes group and control. The frequency of PP and PA genotype in diabetes group were 84.5%, 15.5%, respectively, and in control were 89.1%, 10.9%, respectively. There was no statistically significant difference of Pro12Ala genotype and allele frequency distribution between diabetes group and control. The correlation between PP genotype and Type Ⅱ diabetes by logistic regression analysis after adjustment for age, sex, BMI(P=0.734, OR=1.237, 95% CI: 0.363-4.213). Conclusion The Pro12Ala single nucleotide polymorphism of PPARγ2 was not associated with diabetes.