Expression of Survivin and P-glycoprotein in osteosarcoma and its relationship with chemoresistance

Objective To investigate the expression of Survivin and P-glycoprotein (P-gp) in osteosarcoma and its relationship with the clinical and pathological features of osteosarcoma. Methods The expression of antiapoptotic protein Survivin and P-gp (expressed by multidrug resistance gene mdr1) were detected in 34 cases of osteosarcoma (the study group) and 30 cases of osteochondroma (the control group) using immunohistochemistry (SP method). The relationship between the expression of Survivin and P-gp, as well as its relevance to the clinical and pathological features of osteosarcoma was analyzed. Results ① The positive expression of Survivin protein was found in 19 of the 34 cases of osteosarcoma, accounting for 55.9% (19/34), and the positive expression of P-gp was found in 27 cases (79.4%, 27/34). Specimens in the control group were found with no expression of Survivin and P-gp protein. ② 16 cases in the study group were found with osteosarcoma metastasis. in which the expression of Survivin and P-gp protein was significantly higher than those patients without metastasis (P 0.05). Conclusion Survivin and P-gp show high expression in osteosarcoma, and the expression levels of the two proteins is positively related to tumor grade and metastasis of osteosarcoma.