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2009•Medical Journal of CommunicationsRequires access

The Study of Clinicopathological Significance of Survivin in Esophageal Squamous Cell Carcinoma

Hongbin Liu

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Abstract

Objective: To investigate the clinicopathologic signification of Survivin in Esophageal Squamous Cell Carcinoma (ESCC). Method: The expression of Survivin in 80 ESCC was measured by immunohistochemistry. Results: The positive rate of Survivin expressions was 65%. The positive rate of Survivin had a positive correlation with lymph node metastasis and the clinical stage (P0.05). The positive rate of Survivin was also positively correlated with the degree of ESCC differentiation (P0.05). Conclusion: Survivin was higherly expressed in ESCC than in normal esophageal tissues, and was closely related to lymph node metastasis.

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What this paper is about

Objective: To investigate the clinicopathologic signification of Survivin in Esophageal Squamous Cell Carcinoma (ESCC). Method: The expression of Survivin in 80 ESCC was measured by immunohistochemistry. Results: The positive rate of Survivin expressions was 65%. The positive rate of Survivin had a positive correlation with lymph node metastasis and the clinical stage (P0.05). The positive rate of Survivin was also positively correlated with the degree of ESCC differentiation (P0.05). Conclusion: Survivin was higherly expressed in ESCC than in normal esophageal tissues, and was closely related to lymph node metastasis.

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Available abstract

Objective: To investigate the clinicopathologic signification of Survivin in Esophageal Squamous Cell Carcinoma (ESCC). Method: The expression of Survivin in 80 ESCC was measured by immunohistochemistry. Results: The positive rate of Survivin expressions was 65%. The positive rate of Survivin had a positive correlation with lymph node metastasis and the clinical stage (P0.05). The positive rate of Survivin was also positively correlated with the degree of ESCC differentiation (P0.05). Conclusion: Survivin was higherly expressed in ESCC than in normal esophageal tissues, and was closely related to lymph node metastasis.

Key concepts: Survivin, Lymph node metastasis, Immunohistochemistry, Esophageal squamous cell carcinoma, Stage (stratigraphy), Medicine, Basal cell, Oncology

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