Effect on C-reactive protein,interleukin-6 and intercellular adhesion molecule-1pre-and post-cutting balloon angioplasty

Objective:To study the different effects on C\|reactive protein(CRP),interleukin\|6(IL\|6) and soluble intercellular adhesion molecule\|1(sICAM\|1) between cutting balloon angioplasty and conventional balloon angioplasty.Method:Patients with isolated left anterior descending coronary artery disease were divided into two groups,one group accepted cutting balloon angioplasty,the other group accepted coventional balloon angioplasty.Serum levels of CRP,IL\|6 and sICAM\|1 were measured before,1,6,24,48 hours after angioplasty.Result:The clinic and lesion characteristics were similar in both groups.The levels of CRP and IL\|6 increased at 6 h and reached their maxima at 24 h after angioplasty.The sICAM\|1 level increased at 1 h and reached its peak at 6 h.The levels of sICAM\|1 at 1,6,24,48 hours after cutting balloon angioplasty were lower than that after conventional balloon angioplasty.The CRP and IL\|6 levels at 6,24,48 hours after cutting balloon angioplasty were less than that after conventional balloon angioplasty.The maximum inflation pressure(MIP)of cutting balloon angioplasty was significantly smaller than that of conventional balloon angioplasty.Conclusion:Balloon angioplasty increased CRP,IL\|6 and sICAM\|1 levels.These changes were smaller in the cutting balloon angioplasty group than that in the conventional balloon angioplasty group.This suggests that cutting balloon angioplasty may produce less vessel wall injury,which may account for the lower rate of restenosis.