Clinical observations of platelet aggregation in patients with type II diabetes undergoing percutaneous coronary intervention with clopidogrel treatment

AIM:To examine clopidogrel resistance among patients with type Ⅱ diabetes undergoing percutaneous coronary intervention(PCI) on clopidogrel treatment.METHODS:Forty six patients(11 diabetic and 35 nondiabetic patients) with acute coronary syndrome(ACS) who had undergone PCI were treated with clopidogrel(300 mg loading dose followed by a dose of 75 mg/day).Platelet aggregation function was assessed before and 2,4,6,24,48 and 30 days after clopidogrel treatment.Platelet aggregation and characteristics between groups were compared.RESULTS:The ratio of clopidogrel resistance was much higher in diabetic patients(55%) than in nondiabetic patients(26%)(P0.05).CONCLUSION:Diabetic subjects undergoing PCI have a higher ratio of clopidogrel resistance compared with nondiabetic subjects.