ScholarLens Back to search
2008•Chinese Heart JournalRequires access

Clinical observation of clopidogrel-resistance in patients undergoing percutaneous coronary intervention with clopidogrel

Wang Hong

Open publisher page 0 citations

Abstract

AIM To examine the platelet aggregation and the prevalence of clopidogrel-resistance among patients undergoing percutaneous coronary intervention (PCI). METHODS Thirty-seven patients with acute coronary symptom (ACS) who underwent PCI were treated with clopidogrel (300 mg,loading dose,followed with 75 mg/d). Platelet aggregation function was assessed before and 2,4,6,24,48 h and 30 d after clopidogrel treatment. RESULTS The ratio of clopidogrel resistance were 62%,46%,32%,38%,49% and 43% at different times,platelet inhibition was much lower in clopidogrel resistants than responders,and subacute in-stent thrombosis occurred in one patient with clopidogrel resistance. CONCLUSION Clopidogrel-resistance may occur in some patients undergoing percutaneous coronary intervention.

About this research paper

What this paper is about

AIM To examine the platelet aggregation and the prevalence of clopidogrel-resistance among patients undergoing percutaneous coronary intervention (PCI). METHODS Thirty-seven patients with acute coronary symptom (ACS) who underwent PCI were treated with clopidogrel (300 mg,loading dose,followed with 75 mg/d). Platelet aggregation function was assessed before and 2,4,6,24,48 h and 30 d after clopidogrel treatment. RESULTS The ratio of clopidogrel resistance were 62%,46%,32%,38%,49% and 43% at different times,platelet inhibition was much lower in clopidogrel resistants than responders,and subacute in-stent thrombosis occurred in one patient with clopidogrel resistance. CONCLUSION Clopidogrel-resistance may occur in some patients undergoing percutaneous coronary intervention.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM To examine the platelet aggregation and the prevalence of clopidogrel-resistance among patients undergoing percutaneous coronary intervention (PCI). METHODS Thirty-seven patients with acute coronary symptom (ACS) who underwent PCI were treated with clopidogrel (300 mg,loading dose,followed with 75 mg/d). Platelet aggregation function was assessed before and 2,4,6,24,48 h and 30 d after clopidogrel treatment. RESULTS The ratio of clopidogrel resistance were 62%,46%,32%,38%,49% and 43% at different times,platelet inhibition was much lower in clopidogrel resistants than responders,and subacute in-stent thrombosis occurred in one patient with clopidogrel resistance. CONCLUSION Clopidogrel-resistance may occur in some patients undergoing percutaneous coronary intervention.

Key concepts: Clopidogrel, Percutaneous coronary intervention, Medicine, Conventional PCI, Internal medicine, Cardiology, Platelet, Loading dose

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Clinical observation of clopidogrel-resistance in patients undergoing percutaneous coronary intervention with clopidogrel — Research Paper | ScholarLens