Clopidogrel Low-Responsiveness in Patients with Coronary Artery Disease

Objective:To investigate clopidogrel low-responsiveness(CLR)in the patients with coronary artery disease,and further to evaluate the clinical characteristics of them.Methods:We prospectively enrolled 90 patients with acute coronary syndrome(ACS).of the total there are twenty-seven patients who had undergone percutaneous coronary interventional(PCI) therapy.All patients were received a loading dose of 300 mg clopidogrel followed by a maintenance dose of 75 mg/d.Platelet aggregation ratio induced by adenosine diphosphate(ADP) with a concentration of 5 μmol/L was measured before and 7 days after clopidogrel intake,and the inhibition of platelet aggregation ratio(△A) was calculated,patients were divided into clopidogrel low-responsiveness group and clopidogrel normal-responsiveness group.Results:Of 90 patients,24.4% were CLR.The clinical characteristics of clopidogrel low-responsiveness patients compared with clopidogrel normal-responsiveness patients Total Cholesterol(TC)、Body Mass Index(BMI)、diabetic and percutaneous coronary interventional patients were predominant.Conclusion:Clopidogrel low-response is likely correlated with some clinical such as TC、BMI、diabetic and PCI.