Controlled study on effect of amiodarone and hydrochloric acid propafenone on paroxysmal supraventricular tachycardia

Objective To observe the clinical efficacy and safety of intravenous amiodarone and hydrochloric acid propafenone in treating paroxysmal supraventricular tachycardia.Methods Eighty patients with paroxysmal supraventricular tachycardia were divieded into group A and B randomly(40 cases in each group).Group A received amiodarone,while group B received hydrochloric acid propafenone.The effective rate of cardioversion,cardioversion time,adverse reactions and the heart rate change were compared.Results The effective rate in group A was higher than that in group B,but the difference was not statistically significant.The cardioversion time in group A was obviously longer than that in group B(P0.01).The heart rates in the two groups after treatment decreased obviously(P0.01),while the heart rate in group A was obviously lower than that in group B(P0.01).The incidence of adverse reactions in group A was lower than that in group B,but the difference was not statistically significant.Conclusion There are advantages of both amiodarone and propafenone in the treatment of paroxysmal supraventricular tachycardia.Propafenone is applicable to acute tachycardia,but adverse reactions should be taken into consideration.The amiodarone is effective in the treatment of paroxysmal supraventricular tachycardia in spite of the slow onset.