Preparation of Nimodipine gelatin microspheres and study of its characteristics

OBJECTIVE To explore the process for preparing Nimodipine gelatin microspheres and observe its release characteristics in vitro.METHODS Degradable gelatin was used as a carrier,with liquid paraffin as oil phase,and Span-80 as emulsifier.Orthogonal experimental design was introduced to optimize the preparation conditions of the blank gelatin microspheres.Furthermore,Nimodipine gelatin microspheres were prepared using emulsifiying technique.RESULTS After optimizing,microspheres with good shape,smooth surface and narrow size distribution were prepared.The amount of drug carried by microspheres was 13.48%.The release rate of the micropheres prepared could be appropriately simulated by first order kinetics equation.CONCLUSION The preparation procedure established was stable and practical,and the microspheres obtained showed good sustained-release characteristics.