Effects of lamivudine combining with silybin on secondary cirrhosis induced by hepatitis B

Objective:To investigate the influence of lamivudine combining with silibin on major indicators of liver cirrhosis in patients with hepatitis B.Methods: A total of 64 patients with liver cirrhosis induced by hepatitis B were randomly divided into treatment group and control group and were treated for at least 12 months.Before treatment,half a year after treatment,12 months before and after treatment,major indicators of cirrhosis and liver function were analyzed and compared.Results: The treatment group showed significant obvious improvements in major indicators of cirrhosis and liver function compared with the control group(P0.05).Besides,decrease in AST level 1 year before and after the treatment of the treatment group was also more obvious,and the decrease was correlated with treatment course.Conclusions: Lamivudine combining with silibinin can significantly improve the hepatic fibrosis and liver function indicators in patients cirrhosis induced by hepatitis B