The relationship between the IgG antibody to A (B) titer of type O gravidas and hemolytic disease of the newborn

Objective:To investigate the distribution of type O gravidas(spouses of non-O) pre-IgG anti-A(B)antibody titer and its relationship with hemolytic disease of newborn(HDN) in Ningbo.Methods: Detect the type O gravidas IgG anti-A(B)antibody titer by micro-clumn gel test,and detect three tests by the neonatal HDN trial,the direct antiglobulin test,free test,antibody-released test.Results: 7079 cases of type O gravidas IgG anti-A(B)antibody titer was positively skewed distribution.There were 2848 pregant women IgG anti-A(B)antibody titer≥1∶128(60.0%),in which O-A O-B and O-AB group were 62.7% 50.2% 74.9% respectively,and there were significantly difference among three group(P0.01).With the maternal serum IgG anti-A(B)antibody titer increase gradually,the ABO HDN incidence rate increase gradually.There were significantly difference among the HDN distribution in different lever of antibody titers(P0.01).Conclusion: The type O gravidas IgG anti-A(B)antibody titer was positively skewed distribution.The incidence rate of ABO HDN and IgG anti-A(B)antibody titer were positively correlated.When the IgG anti-A(B)antibody titer ≥1∶128 ABO HDN incidence rate were significantly higher.